NSC 705701
Alsterpaullone
CAS: 237430-03-4
Molecular Formula: C16H11N3O3
NSC 705701 - Names and Identifiers
NSC 705701 - Physico-chemical Properties
| Molecular Formula | C16H11N3O3 |
| Molar Mass | 293.28 |
| Density | 1.461±0.06 g/cm3(Predicted) |
| Melting Point | >330℃ |
| Boling Point | 651.5±45.0 °C(Predicted) |
| Solubility | DMSO: soluble |
| Appearance | powder |
| Color | brown |
| pKa | 14.18±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Use | Alsterpaullone (9-Nitropaullone) is a highly effective CDK inhibitor. The IC50 values of CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35 are 35 nM, 15 nM, 200 nM and 40 nM respectively. Alsterpaullone is a competitive GSK-3alpha/GSK-3beta inhibitor of ATP, and the IC50 value of the action is 4 nM. Alsterpaullone has anti-tumor activity and has the potential to be used in the research of neurodegenerative and proliferative diseases. |
NSC 705701 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
NSC 705701 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.41 ml | 17.049 ml | 34.097 ml |
| 5 mM | 0.682 ml | 3.41 ml | 6.819 ml |
| 10 mM | 0.341 ml | 1.705 ml | 3.41 ml |
| 5 mM | 0.068 ml | 0.341 ml | 0.682 ml |
Last Update：2024-01-02 23:10:35
NSC 705701 - Reference Information
| biological activity | alsterpaulone (Alp, 9-nitropaulone, NSC 705701) is a potent inhibitor of CDK, the IC50 values for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35 were 35 nM, 15 nM, 200 nM and 40 nM, respectively. Alsterpaulone is also a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with an IC50 value of 4 nM for both GSK-3α and GSK-3β. Alsterpaulone can induce apoptosis by activating caspase-9. Alsterpaulone has anti-tumor activity and has the potential to treat neurodegenerative and proliferative diseases. |
| Target | Value |
| caspase-9 () | |
| GSK-3α (Cell-free assay) | 4 nM |
| GSK-3β (Cell-free assay) | 4 nM |
| CDK2/cyclin A (Cell-free assay) | 15 nM |
| CDK1/cyclin B (Cell-free assay) | 35 nM |
Last Update：2024-04-10 22:29:15
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Product Name: Alsterpaullone Visit Supplier Webpage Request for quotationCAS: 237430-03-4
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Spot supply
Product Name: Alsterpaullone Visit Supplier Webpage Request for quotationCAS: 237430-03-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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